Science Impact Metalloproteins Outrunning X-ray radiation damage with the use of X-ray FELs, like LCLS, enables the determination of room temperature metalloprotein structures. Membrane Proteins Measuring X-ray diffraction from nanocrystals using X-ray FELs like LCLS allows structures of difficult-to-crystallize proteins to be determined. Photoactive Proteins LCLS has allowed studying the active state structure of photosensitive proteins from femto- to milliseconds after photoactivation. Structural Enzymology X-ray free electron lasers like LCLS have become vital for studying the structural rearrangements in enzymes during biological reactions. Structure-Based Drug Design Solving structures at ambient temperature with minimal radiation damage through LCLS provides more accurate information on binding pockets.
