The unique pulse structure of X-ray free electron lasers like LCLS deliver the necessary number of X-rays to obtain atomic-resolution data from biomolecules before the onset of X-ray radiation damage.

Pocket in an enzyme called ECR where the carbon fixing reaction takes place.

Biomolecules perform many amazing functions, and to understand their actions, it is necessary to determine how their amino acids and atoms evolve over time.

The Horse in Motion photograph by Eadweard Muybridge (1878)

At LCLS, X-ray spectroscopy is utilized with the powerful ultrafast X-ray beam to explore systems at unprecedented timescales and sizes.

A graphic representation of an intermediate chemical reaction and the X-rays, laser and detector.

The LCLS delivers pulses with an intensity that near atomic-resolution structural information can be obtained from individual biomolecules, eliminating the need for crystallography.

Image of the classification of diffraction patterns by EM clustering